Several years ago, I shot a big Ohio buck at about 12 yards through both shoulders on purpose with a 650 grain 28%+/- FOC arrow with a Grizzly single bevel broadhead. Upon receipt of the arrow, the buck went to take another step and neither of his front legs worked any longer. He face planted and pushed himself along on his nose with his hind legs off into a creek where he expired shortly afterward. The arrow went through the onside shoulder and completely severed the offside humorous bone. This was with a 60 pound draw weight Mathews Helim compound.
Season before last, I shot a buck slight quartering too through the shoulder and out behind the shoulder at about 17 yards with a lighter arrow setup weighing 585 grains and about 22% FOC. This was another grizzly single bevel. It went through the scapula on the onside and ribs on exit. The buck trotted 25 yards, stood there nervously, then tipped over dead.
I mostly shoot this 585 grain setup since it tunes to both of my compounds, one 44 and one 60 pounds. It is plenty for our smaller bodied Southern deer. If I go up North again, I will likely pack a little more heat, lol.