Same here, I abandoned several hunts this year due to wind shifts. I throw a lot of milkweed and learn what thermals do, I don’t ever sit where I think I’m doing scent damage.
My scent control was probably more on point five years ago, and has only slipped due to time constraints... I still launder pretty frequently in non scent detergent, store garments in sealed totes, don’t rewear them many times, and everything gets an ozone bath every now and then. My boots are in a tote that has a sealed bag of activated carbon in it, I douse the boots with the carbon with a paintbrush before hunts. So nothing crazy, but yes each hunt requires traveling and time so I do the best I can to have the smallest scent footprint I can and tip the odds. Especially considering some of the best buck setups is where the wind is almost wrong, I try to make that detection cone as faint as possible.
For what it’s worth I’ve shot about six large mature bucks and three of those spent some time downwind. Who knows if they would have pegged me if I was stinkier, but I bet they might have.
This year I was sitting a stand where I was about 350 yards downwind of a neighbors house, I could smell their laundry detergent coming out of the dryer vent, it was unmistakeable. That was an interesting observation.