Just skimmed some of the other replies I may be repeating what some have said but here's my 3 cents
I cut my teeth hunting mountain deer. Dad didn't know any different and we had access to a large tract of private.
That ecosystem just doesn't support deer like the foothills and lowlands and can easily make you hate deer hunting. If you're not really on top of things you will spend a ton of time seeing a whole lot of nothing.
Even if you are on top of things opportunities will be few and far between with the lower deer density. You better be able to take your time in a hurry.
That being said sign is fine and all but it doesn't mean much to me and I absolutely won't camp on it. Only time I'll fool with it is mid to late oct after a rain when they have a little piss and vinegar going and that's mostly for the novelty of it.
Some of my best spots ever are barren of sign and trails and hanging a camera in there would just make you think nothing is going on in that spot as no two deer walk the same path through it.
Without going into hyper detail a great way to whittle down the big woods is to of course read the topo, 9 times out of 10 they are going to take the path of least resistance. However all topo is not equal. Sure a random saddle on a ridge will have deer pass through at some point but how often.
You need to determine the significance of each topographical feature. Diversity and relative topography will dictate the significance of each topo feature.
Sure deer can be killed in bland random topography, but when you're faced with whittling down 20 to 100,000 acre and beyond rugged tracts you've got to have some confidence in some consistent topo and Diversity features that produce replicable hunting experiences no matter whether you hunt.
Sometimes there's no old clearcuts/meadows/swamps/adjacent cow pastures to key in on the topo in proximity of.
Often times you are faced with strictly "ivy" (that's what the old timers call mountain laurel or rhododendron interchangeably here)
Think of It like reservoirs and rivers, dont overlook streaks of hemlock or pine either.
A great place to key in on any time but especially cold days in the rut is where rivers of ivy intersect, especially when paired with path of least resistance topography.
Get Google earth or anything that shows historical satellite imagery and go to when the leaves are off. Ideally you can find where the vegetation is least obstructive while maximizing shot opportunities in the topo feature. More often than not this is sufficient when gun hunting but generally takes a little on site tweaking for archery.
Often I'll get right on the x of the ivy streaks so I can shoot either side of the laurel.
And yeah its not the Midwest or Texas brush country but a deer is a deer and I rattle my ass off in late oct and early November. I could care less what it scares off cause I'm only after what it brings in anyway. I have had some magical days in late October with my bow. Especially on the first cold snap of the year. You aren't going to call one into the wide open but he'll make a bee line to the base of your tree if your in the the laurel.
I rate each as 1,2,3 dimensional and so on. Generally the more dimensions you delineate the higher the frequency of deer passing through.
There is no substitute for time spent in the tree. Don't write off a spot over a couple skunk sits. Take up squirrel hunting, turkey hunting. Romp that mountain down and take notes. There's spots that scream at you from the map and there's ones that you'd never know they were there unless you were standing in em.
When you are walking in the off season with the leaves off take the time to mull over spots and pick trees that present the most shot opportunities, dont half ass tree picking when you have the time. Then ring the the tree with a few cat eyes and drop a pin on it so you can find it in the dark even years later. I like to bring a 2tc stirrup strap and get them up in the air some (probably overkill but if you can't tell by now I'm prone to that).
One more thing that's worth noting is Google maps has a relief layer that shows the topography in extreme detail albeit its not super close up in its most detailed extent. I'll often look at it drop a pin on the subtle feature you can't see on a regular topo map and copy the coordinates onto Onx to save.
As if I haven't already I could go on and on but I better go do something productive. Good luck