One of the several goals that I set for myself this year was to really ramp up the amount of preset "stands" I have available to hunt. Run-and-gun is nice, but there are huge benefits of having a large number of ready to go trees in strategic locations.
Stealth is perhaps the biggest advantage. You cannot climb a tree with steps, sticks, spurs, or bolts as quietly as you can a preset tree. You can come close, but there is always more noise, movement, and effort involved.
Time is another big factor. I can walk up to a prepped tree, shimmy up, and be tethered in in just a couple of minutes. In areas way off the beaten path, saving a few minutes can be the difference between beating deer movement. It's also nice for those quickie before or after work hunts.
I am also more confident hunting prepped trees. Something about following a marked trail straight to a tree and quietly getting setup with a minimum of sweat and time just seems to put me in the right mindset. "Everything is according to plan."
This video shows the tools I use to efficiently preset trees, and discusses how I go about the process for public and private land.