What are you looking to accomplish asking the question here?
Holes drilled in trees with less dense or softer wood, or trees with thicker sap wood (generally less dense and softer than heart wood) will not hold up as well to the forces imparted by a bolt with you standing on it. This is relative to harder woods. And must take into account bolt surface area, your weight, etc.
"safe" is not black and white.
Someone who weighs 150lbs, standing on the same bolt, inserted the same length, in a tree in a different part of the country, could have a wildly different outcome than you.
If the hole elongates, and the bolt has the potential to be oriented beyond parallel to the ground, I think most folks would consider that "unsafe" in the context of tree climbing.
Question - would you drill a tree with a bolt at less than 90* to the ground and then climb on it? My guess is no. Why then, would you have to introduce the opinion of strangers into the equation of whether you'd climb on a bolt that is less than 90* in relation to the ground after the hole has been elongated? Does it matter how it got there?